JD-5037
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- CAS號(hào):
- 1392116-14-1
- 英文名:
- JD-5037
- 英文別名:
- CS-2558;JD-5037;JD 5037;JD-5037;JD-5037, 10 mM in DMSO;Cannabinoid Receptor,inhibit,JD5037,JD-5037,Inhibitor;(S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide;(S)-2-((Z)-(((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide;(S)-2-(((E)-((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)((4-chlorophenyl)sulfonamido)methylene)amino)-3-methylbutanamide;Butanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)-
- 中文名:
- JD-5037
- 中文別名:
- 化合物JD5037;化合物JD5037,10 MM DMSO 溶液;(S)-2-((((S)-3-(4-氯苯基)-4-苯基-4,5-二氫-1H-吡唑-1-基)(4-氯苯基磺胺基)亞甲基)氨基)-3-甲基丁酰胺
- CBNumber:
- CB23167616
- 分子式:
- C27H27Cl2N5O3S
- 分子量:
- 572.51
- MOL File:
- 1392116-14-1.mol
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JD-5037化學(xué)性質(zhì)
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沸點(diǎn):
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721.6±70.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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≥143.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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10.63±0.60(Predicted)
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顏色:
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White to off-white
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JD-5037性質(zhì)、用途與生產(chǎn)工藝
JD-5037是cannabinoid-1 receptor阻滯劑，對(duì)CB1受體的IC50值為2 nM，而對(duì)CB2受體的IC50值大于1000 nM。
| Target | Value |
CB1 receptor
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2 nM
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JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia, and reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice.
JD-5037
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-18697 | JD-5037 | 1392116-14-1 | 1 mg | 390元 |
| 2025/02/08 | HY-18697 | JD-5037
JD-5037 | 1392116-14-1 | 5mg | 860元 |
1392116-14-1, JD-5037 相關(guān)搜索:
- 抑制劑
- 合成有機(jī)化合物配體
- C27H27Cl2N5O3S
- 化合物JD5037,10 MM DMSO 溶液
- (S)-2-((((S)-3-(4-氯苯基)-4-苯基-4,5-二氫-1H-吡唑-1-基)(4-氯苯基磺胺基)亞甲基)氨基)-3-甲基丁酰胺
- 化合物JD5037
- 1392116-14-1
- (S)-2-(((E)-((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)((4-chlorophenyl)sulfonamido)methylene)amino)-3-methylbutanamide
- JD-5037, 10 mM in DMSO
- (S)-2-((((S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide
- Cannabinoid Receptor,inhibit,JD5037,JD-5037,Inhibitor
- Butanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)-
- JD 5037;JD-5037
- CS-2558
- (S)-2-((Z)-(((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenylsulfonamido)methylene)amino)-3-methylbutanamide
- JD-5037