DBCO-PEG4-amine
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- CAS號:
- 1840886-10-3
- 英文名:
- DBCO-PEG4-amine
- 英文別名:
- DBCO-CONH-PEG4-amine;DBCO-PEG2-amine TFA salt;DBCO-PEG4-amine TFA salt;Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-;N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
- 中文名:
- DBCO-PEG4-amine
- 中文別名:
- 二苯并環(huán)辛炔-四聚乙二醇-胺;二苯基環(huán)辛炔-四聚乙二醇-胺;二苯并環(huán)辛炔-四聚乙二醇-氨基
- CBNumber:
- CB14849428
- 分子式:
- C29H37N3O6
- 分子量:
- 523.63
- MOL File:
- 1840886-10-3.mol
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DBCO-PEG4-amine化學(xué)性質(zhì)
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沸點:
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784.1±60.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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溶解度:
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Soluble in DMSO, DCM, DMF
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酸度系數(shù)(pKa):
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15.14±0.46(Predicted)
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形態(tài):
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Viscous Liquid
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顏色:
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Light yellow to yellow
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InChIKey:
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NFJQULPXXATMFO-UHFFFAOYSA-N
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SMILES:
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C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN
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DBCO-PEG4-amine性質(zhì)、用途與生產(chǎn)工藝
DBCO-PEG4-amine 是一種 PROTAC 連接橋，屬于 PEG 類。DBCO-PEG4-amine 可用于合成一系列 PROTAC 分子。DBCO-PEG4-amine 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。DBCO-PEG4-amine 可用來合成一種同雙功能疊氮化物至疊氮化物交聯(lián)劑 FPM-PEG4-DBCO。
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
DBCO-PEG4-amine
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
DBCO-PEG4-amine
生產(chǎn)廠家
1840886-10-3, DBCO-PEG4-amine 相關(guān)搜索:
- 二苯并環(huán)辛炔-四聚乙二醇-氨基
- 二苯并環(huán)辛炔-四聚乙二醇-胺
- 二苯基環(huán)辛炔-四聚乙二醇-胺
- 1840886-10-3
- DBCO-CONH-PEG4-amine
- N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide
- Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo-
- DBCO-PEG2-amine TFA salt
- DBCO-PEG4-amine TFA salt