泊沙康唑主環(huán)性質(zhì)、用途與生產(chǎn)工藝

概述

泊沙康唑主環(huán)(posaconazole)是伊曲康唑的衍生物，于2006年在FDA上市的第二代三唑類抗真菌藥物，商品名為NOXAFIL，原研廠家為先靈葆雅。

制備

先靈葆雅于1995年在US5661151A公開了泊沙康唑主環(huán)的合成路線，它以2'-氯-2,4-二氟苯乙酮為起始原料，通過Wittig反應(yīng)，構(gòu)型的翻轉(zhuǎn)，最終得到終產(chǎn)品。

泊沙康唑主環(huán) 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

泊沙康唑主環(huán) 生產(chǎn)廠家

175712-02-4, 泊沙康唑主環(huán) 相關(guān)搜索:

• 主打產(chǎn)品
• 系列1
• 雜質(zhì)對(duì)照品
• 抗菌
• 對(duì)照品-雜質(zhì)對(duì)照品
• 中間體
• 醫(yī)藥中間體
• C20H18ClF2N3O4S
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氫呋喃-3-甲基]對(duì)…
• 泊沙康唑主環(huán)M10A
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)甲基4-氯苯磺酸酯(POS85-V)
• 泊沙康唑主環(huán)2(CBSCL)
• 4-氯苯磺酸5-(2,4-二氟苯基)-5-[1,2,4]三唑-1-基甲基四氫呋喃-3-基甲酯
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)甲基4-氯苯磺酸酯
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氫呋喃-3-基)4-氯苯磺酸甲酯
• B泊沙康唑雜質(zhì)14
• 泊沙康唑雜質(zhì)106
• 泊沙康唑主環(huán)
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氫呋喃-3-甲基]對(duì)氯苯磺酸酯,泊沙康唑中間體
• 泊沙康唑主環(huán)(對(duì)氯保護(hù)基)
• 泊沙康唑氯代
• 泊沙康唑主環(huán)(含對(duì)氯苯磺酸保護(hù)基)
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氫呋喃-3-甲基]對(duì)氯苯磺酸酯,泊沙康唑中間體 500G
• 泊沙對(duì)氯主環(huán)
• (3S-順式)-4-氯苯磺酸[5-(2,4-二氟苯基)四氫-5-(1H-1,2,4-三唑-1-基甲基)-3-呋喃基]甲基酯
• 泊沙康唑中間體9
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氫呋喃-3-甲基]對(duì)氯苯磺酸酯
• 175712-02-4
• (3S-cis)-4-Chlorobenzenesulfonic acid [5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methyl
• N-(2-((4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)amino)ethyl)-N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)formamide
• "D-THREO-PENTITOL 2 5-ANHYDRO-4-[[[(4-CHLOROPHENYL)SULFONYL]OXY]METHYL]-1 3 4-TRIDEOXY-2-C-(2 4-DIFLUOROPHENYL)-1-(1H-1 2 4-TRIA
• Posaconazole Intermediate 9
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)...
• Posaconazole POA
• Posaconazole Impurity 106
• D-threo-Pentitol, 2,5-anhydro-4-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-chlorobenzenesulfonate
• EOS-60774
• 4-difluoro-phenyl)-5-[1
• 4-Chloro-benzenesulfonic acid 5-(2
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl esterChemicalBook
• (3S,5R)-5-(2,4-difluoro-phenyl)-5-1,2,4triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl 4-chlorobenzenesulfote
• ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl4-chlorobenzenesulfonate
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetra hydrofuran-3-yl]methyl 4-chlorobenzenesulfonate
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methyl 4-chlorobenzenesulfonate 4-Chloro-benzenesulfonic acid
• 2,5-Anhydro-4-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
• (3S-cis)-4-Chlorobenzenesulfonic acid [5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methyl ester
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester