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105963-46-0

105963-46-0, 105963-46-0, 結(jié)構(gòu)式
105963-46-0
CAS號(hào):
105963-46-0
英文名:
TOK 8801
英文別名:
TOK 8801;TOK 8801,TOK8801;3,6,6-trimethyl-N-(2-phenylethyl)-5H,6H-imidazo[2,1-b][1,3]thiazole-2-carboxamide;Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-
中文名:
105963-46-0
中文別名:
化合物 T13180;化合物 TOK-8801
CBNumber:
CB11322382
分子式:
C17H21N3OS
分子量:
315.439
MOL File:
105963-46-0.mol

105963-46-0化學(xué)性質(zhì)

密度:
1.23±0.1 g/cm3(Predicted)
儲(chǔ)存條件:
Store at -20°C
溶解度:
Soluble in DMSO
酸度系數(shù)(pKa):
13.27±0.40(Predicted)
安全信息

105963-46-0性質(zhì)、用途與生產(chǎn)工藝

生物活性

TOK-8801 是一種合成的二氫咪唑并噻唑羧酰胺,正在開(kāi)發(fā)作為免疫調(diào)節(jié)劑。

體外研究

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator. TOK-8801 augments the in vitro anti-SRBC PFC response of murine splenocytes in a bell-shaped manner. The stimulatory effect of TOK-8801 is observed at concentrations of 2.5×10 -7 to 2.5×10 -5 M and is diminished at 10 -4 M. The cell-viability is not altered during the culture with TOK-8801 at any doses used in this experiment (10 -7 to 10 -4 M). TOK-8801 enhances the 3 H-TdR uptake of these responses in a bell-shaped manner, and effective concentrations of TOK-8801 are 10 -7 to 10 -5 M.

體內(nèi)研究

The anti-SRBC PFC response per spleen, which is prominently lowered by restraint-stress (P<0.05), is significantly restored by the administration of TOK-8801 (0.5 mg/kg, P<0.05). The number of total splenic lymphocytes in restraint-stress is decreased, but there are no significant changes in the number of total splenic lymphocytes by the treatment with TOK-8801. When TOK-8801 is administered orally at doses of 0.1 to 10 mg/kg, the number of plaque forming cell (PFC) significantly decreases or tends to decrease. Treatment of TOK-8801 at doses of 0.1 to 1 mg/kg causes significant suppression in the delayed-type hypersensitivity (DTH) reaction induced in high responder.

105963-46-0 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品


105963-46-0 生產(chǎn)廠家

全球有 16家供應(yīng)商   105963-46-0國(guó)內(nèi)生產(chǎn)廠家
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MedChemexpress LLC 021-58955995 sales@medchemexpress.cn 美國(guó) 4861 58
上海樓嵐生物科技有限公司 021-52996696,15000506266 15000506266 中國(guó) 4613 55
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美國(guó) 32265 58
天津普西唐生物醫(yī)藥科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中國(guó) 29774 58
TargetMol中國(guó)(陶術(shù)生物) 4008200310 marketing@tsbiochem.com 中國(guó) 24843 58
上海一飛生物科技有限公司 021-65675885 18964387627 customer_service@efebio.com 中國(guó) 11973 58
生工生物工程(上海)股份有限公司 400-821-026 Sales@sangon.com 中國(guó) 48813 58
寶歐信特生物科技(蘇州)有限公司 51288865780 sales@biosynth.com 中國(guó) 233051 58
南京百鑫德諾生物科技有限公司 400-025-6535 sales@adooq.cn 中國(guó) 18215 58
TargetMol Chemicals Inc. support@targetmol.com 美國(guó) 38659 58
 

105963-46-0, 105963-46-0 相關(guān)搜索:

  • 抑制劑
  • 化合物 TOK-8801
  • 化合物 T13180
  • 105963-46-0
  • 3,6,6-trimethyl-N-(2-phenylethyl)-5H,6H-imidazo[2,1-b][1,3]thiazole-2-carboxamide
  • TOK 8801,TOK8801
  • Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-
  • TOK 8801
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