105963-46-0
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- CAS號(hào):
- 105963-46-0
- 英文名:
- TOK 8801
- 英文別名:
- TOK 8801;TOK 8801,TOK8801;3,6,6-trimethyl-N-(2-phenylethyl)-5H,6H-imidazo[2,1-b][1,3]thiazole-2-carboxamide;Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-
- 中文名:
- 105963-46-0
- 中文別名:
- 化合物 T13180;化合物 TOK-8801
- CBNumber:
- CB11322382
- 分子式:
- C17H21N3OS
- 分子量:
- 315.439
- MOL File:
- 105963-46-0.mol
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105963-46-0化學(xué)性質(zhì)
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密度:
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1.23±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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13.27±0.40(Predicted)
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105963-46-0性質(zhì)、用途與生產(chǎn)工藝
TOK-8801 是一種合成的二氫咪唑并噻唑羧酰胺,正在開(kāi)發(fā)作為免疫調(diào)節(jié)劑。
TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator. TOK-8801 augments the
in vitro
anti-SRBC PFC response of murine splenocytes in a bell-shaped manner. The stimulatory effect of TOK-8801 is observed at concentrations of 2.5×10
-7
to 2.5×10
-5
M and is diminished at 10
-4
M. The cell-viability is not altered during the culture with TOK-8801 at any doses used in this experiment (10
-7
to 10
-4
M). TOK-8801 enhances the
3
H-TdR uptake of these responses in a bell-shaped manner, and effective concentrations of TOK-8801 are 10
-7
to 10
-5
M.
The anti-SRBC PFC response per spleen, which is prominently lowered by restraint-stress (P<0.05), is significantly restored by the administration of TOK-8801 (0.5 mg/kg, P<0.05). The number of total splenic lymphocytes in restraint-stress is decreased, but there are no significant changes in the number of total splenic lymphocytes by the treatment with TOK-8801. When TOK-8801 is administered orally at doses of 0.1 to 10 mg/kg, the number of plaque forming cell (PFC) significantly decreases or tends to decrease. Treatment of TOK-8801 at doses of 0.1 to 1 mg/kg causes significant suppression in the delayed-type hypersensitivity (DTH) reaction induced in high responder.
105963-46-0
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105963-46-0, 105963-46-0 相關(guān)搜索:
- 抑制劑
- 化合物 TOK-8801
- 化合物 T13180
- 105963-46-0
- 3,6,6-trimethyl-N-(2-phenylethyl)-5H,6H-imidazo[2,1-b][1,3]thiazole-2-carboxamide
- TOK 8801,TOK8801
- Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-
- TOK 8801