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Difamilast

Difamilast Struktur
937782-05-3
CAS-Nr.
937782-05-3
Englisch Name:
Difamilast
Synonyma:
OPA15406);Difamilast;Difamilast (OPA-15406;Difamilast 937782-05-3;N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide;N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide;Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-;Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
CBNumber:
CB64694667
Summenformel:
C23H24F2N2O5
Molgewicht:
446.44
MOL-Datei:
937782-05-3.mol

Difamilast Eigenschaften

Dichte
1.223±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : 100 mg/mL (223.99 mM; Need ultrasonic)
pka
13.12±0.46(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChI
InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28)
InChIKey
VFBILHPIHUPBPZ-UHFFFAOYSA-N
SMILES
C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)(=O)C1=CC=CC=C1OCC

Sicherheit

Difamilast Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivit?t

Difamilast is a novel atopic dermatitis drug candidate discovered by Otsuka that has phosphodiesterase 4 (PDE4) inhibitory activity. 

Difamilast Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Difamilast Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 35)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106
sales@trywchem.com China 148 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Jiangxi Huihe Chemical Co., Ltd.
+86-19189228086 +8618858568638
wuzhouding@huihecrop.com China 886 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636
wtx@bayeebio.com China 261 61
Hefei TianRui Pharmaceutical Chemistry Co., Ltd. 0551-68933033 13956024211
trchem@163.com China 87 58
Shanghai Yatan Pharmaceutical Research and Development Co. LTD 021-58003085 15865876430
hujy@neutanpharma.com China 173 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070
info@chemlin.com.cn China 19179 64
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232
1282296214@qq.com China 491 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
sales-cpd@caerulumpharma.com China 3466 58

  • Difamilast 937782-05-3
  • Difamilast (OPA-15406
  • OPA15406)
  • Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-
  • N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide
  • Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
  • Difamilast
  • N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide
  • 937782-05-3
  • API
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