DJ-V159
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- CAS號:
- 2253744-53-3
- 英文名:
- DJ-V159
- 英文別名:
- DJ-V159;DJ-V159;DJ-V 159;DJ-V-159, 10 mM in DMSO;DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159;1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
- 中文名:
- DJ-V159
- 中文別名:
- 化合物DJ-V159;化合物DJ-V159,10 MM DMSO 溶液;N1,N3-雙(4-氰基-3-(三氟甲基)苯基)間苯二甲酰胺
- CBNumber:
- CB04804691
- 分子式:
- C24H12F6N4O2
- 分子量:
- 502.37
- MOL File:
- 2253744-53-3.mol
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DJ-V159化學性質(zhì)
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儲存條件:
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RT
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溶解度:
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Soluble in DMSO (up to 60 mg/ml).
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形態(tài):
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solid
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顏色:
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Off-white
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穩(wěn)定性:
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Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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DJ-V159性質(zhì)、用途與生產(chǎn)工藝
DJ-V-159 是G蛋白偶聯(lián)受體家族C組6 A (GPRC6A) 的激動劑。
DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A.
DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five.
DJ-V159
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/02/05 | HY-114165 | DJ-V159
DJ-V-159 | 2253744-53-3 | 5mg | 420元 |
| 2025/02/05 | HY-114165 | DJ-V159
DJ-V-159 | 2253744-53-3 | 10mM * 1mLin DMSO | 464元 |
2253744-53-3, DJ-V159 相關搜索:
- 抑制劑
- 藥靶配體
- 化合物DJ-V159,10 MM DMSO 溶液
- N1,N3-雙(4-氰基-3-(三氟甲基)苯基)間苯二甲酰胺
- 化合物DJ-V159
- 2253744-53-3
- DJ-V-159, 10 mM in DMSO
- DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159
- 1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
- DJ-V159;DJ-V 159
- DJ-V159