99697-24-2
中文名稱
熊去氧膽酸雜質(zhì)24
CAS
99697-24-2
分子式
C23H38O4
分子量
378.55
MOL 文件
99697-24-2.mol
更新日期
2024/06/20 21:07:20
99697-24-2 結(jié)構(gòu)式
基本信息
中文別名
24-去甲氧基膽酸24-去甲熊去氧膽酸(NOR-UDCA)
化合物24-NORURSODEOXYCHOLIC ACID
英文別名
nor-UDCANorursodeoxycholic Acid
24-norursodeoxycholic acid
3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic Acid
(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid
物理化學(xué)性質(zhì)
沸點(diǎn)536.7±25.0 °C(Predicted)
密度1.142±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.71±0.10(Predicted)
常見問題列表
生物活性
24-norursodeoxycholic acid (norUDCA) 是側(cè)鏈縮短的 UDCA 的 C23 同系物，具有有效的抗膽汁淤積，抗炎和抗纖維化特性。體外研究
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels.