99009-20-8
中文名稱
NSC 366140 無結(jié)構(gòu)圖
英文名稱
NSC 366140
CAS
99009-20-8
分子式
C19H21N5O3
分子量
367.4
MOL 文件
99009-20-8.mol
更新日期
2023/03/20 15:41:25
99009-20-8 結(jié)構(gòu)式
基本信息
中文別名
NSC 366140 無結(jié)構(gòu)圖 英文別名
Pd 115934NSC 366140
Pd 115,934
Brn 4211902
Pyrazoloacridine
N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine
Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-
9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine
(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE
2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine
物理化學(xué)性質(zhì)
沸點(diǎn)584.3±50.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)9.35±0.28(Predicted)
形態(tài)Solid
顏色Light brown to orange
NSC 366140 無結(jié)構(gòu)圖價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 5mg | 900元 |
| 2024/11/08 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 10 mg | 1450元 |
| 2024/11/08 | HY-108969 | NSC 366140 無結(jié)構(gòu)圖 Pyrazoloacridine | 99009-20-8 | 25 mg | 2700元 |
常見問題列表
生物活性
Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓?fù)洚悩?gòu)酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 對(duì) K562 髓系白血病細(xì)胞中的 IC50 值為 1.25 μM (24 h)。體外研究
Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC
50
values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.
Pyrazoloacridine (NSC 366140) induces
apoptosis
in P53-deficient Hep 3B human hepatoma cells.
Cell Cytotoxicity Assay
| Cell Line: | K562 Myeloid Leukemia Cells. |
| Concentration: | 0-500 μM. |
| Incubation Time: | 1 h or 24 h. |
| Result: | When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM. |