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98474-59-0

中文名稱 豚鼠髓磷脂堿性蛋白片段68-82
英文名稱 TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN
CAS 98474-59-0
分子式 C71H113N23O28
分子量 1736.81
MOL 文件 98474-59-0.mol
更新日期 2024/12/16 10:25:32
98474-59-0 結(jié)構(gòu)式 98474-59-0 結(jié)構(gòu)式

基本信息

中文別名
髓鞘堿性蛋白豚鼠片段 68-82
豚鼠髓磷脂堿性蛋白片段68-82
L-酪氨酰甘氨酰-L-絲氨酰-L-亮氨酰-L-脯氨酰-L-谷氨酰胺酰-L-賴氨酰-L-絲氨酰-L-谷氨酰胺酰-L-精氨酰-L-絲氨酰-L-谷氨酰胺酰-L-ALPHA-天冬氨酰-L-ALPHA-谷氨酰-L-天冬氨酰胺
英文別名
des-Gly77
MYELIN BASIC PROTEIN, FRAGMENT 68-82
MYELIN BASIC PROTEIN (68-82), GUINEA PIG
(Des-Gly77,Des-His78)-MBP (68-84) (bovine)
MYELIN BASIC PROTEIN MBP (68-82), GUINEA PIG
MYELIN BASIC PROTEIN FRAGMENT 68-82 GUINEA PIG
myelin basic protein guinea pig fragment 68-82
(Des-Gly77,Des-His78)-MBP (68-84) (guinea pig)
DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64
DES-[GLY77,HIS78] MYELIN BASIC PROTEIN (68-84), BOVINE
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

儲(chǔ)存條件−20°C
溶解度insoluble in EtOH; ≥173.6 mg/mL in DMSO; ≥54.6 mg/mL in H2O
形態(tài)固體
顏色White to off-white
序列H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH

安全數(shù)據(jù)

WGK Germany3

常見問題列表

概述
髓磷脂堿性蛋白(myelinbasicprotein,MBP)是髓鞘的主要成分,是誘導(dǎo)實(shí)驗(yàn)性自身免疫性腦脊髓炎(experimentalautoimmuneencephalomyelitis,EAE)的重要抗原。EAE的病理學(xué)特征是:CNS血管周圍大量單個(gè)核細(xì)胞浸潤并造成炎性損傷,用MBP加佐劑主動(dòng)免疫敏感動(dòng)物或過繼轉(zhuǎn)移MBP特異性CD4+T細(xì)胞都可引發(fā)EAE。然而,將MBP致敏的T淋巴細(xì)胞直接注入實(shí)驗(yàn)動(dòng)物的CNS不能誘發(fā)EAE,但將同樣數(shù)量MBP致敏的T淋巴細(xì)胞由皮下或外周注射均可引起EAE,提示在外周針對(duì)MBP的淋巴細(xì)胞活化和活化后穿過血腦屏障是致病的重要因素。豚鼠髓磷脂堿性蛋白片段68-82是髓鞘堿性蛋白(MBP)的一個(gè)片段,結(jié)構(gòu)為tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn
生物活性
Myelin Basic Protein (MBP) (68-82), guinea pig 是髓鞘堿性蛋白 (MBP) 的一個(gè)片段。
體外研究

Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples are analyzed for activation capacity and the activatability of CD4 + and CD8 + T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4 + and CD8 + T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82)).

體內(nèi)研究

Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP?+?BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP?+?BVA group as compared to rats in the MBP group.

豚鼠髓磷脂堿性蛋白片段68-82價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-P1048豚鼠髓磷脂堿性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig
98474-59-01mg700元
2024/11/08HY-P1048豚鼠髓磷脂堿性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig
98474-59-05mg1500元
2024/11/08HY-P1048豚鼠髓磷脂堿性蛋白片段68-82
Myelin Basic Protein (MBP) (68-82), guinea pig
98474-59-010mg2400元
"98474-59-0" 相關(guān)產(chǎn)品信息
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