98457-88-6
中文名稱
化合物 T25079
英文名稱
aminopterin N-hydroxysuccinimide ester
CAS
98457-88-6
分子式
C24H25N9O7
MOL 文件
98457-88-6.mol
98457-88-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T25079 英文別名
Nhs-aminopterinN-Hydroxysuccinimide aminopterin
aminopterin N-hydroxysuccinimide ester
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid
應用領域
用途一
Aminopterin N-hydroxysuccinimide ester is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.