956901-32-9
中文名稱(chēng)
BETAMETHASONE HYDROCHLORIDE
英文名稱(chēng)
BetaMethasone (hydrochloride)
CAS
956901-32-9
分子式
C28H38ClFO7
分子量
541.049
MOL 文件
956901-32-9.mol
956901-32-9 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形態(tài)粉末
常見(jiàn)問(wèn)題列表
生物活性
Betamethasone hydrochloride 是一種合成糖皮質(zhì)激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎兒肺成熟并誘導(dǎo)基因表達(dá)和細(xì)胞凋亡。體外研究
Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.
體內(nèi)研究
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation.
Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.
| Animal Model: | Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges |
| Dosage: | 0.48 mg |
| Administration: | Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h. |
| Result: |
Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion. |