945725-50-8
中文名稱
TASP 0277308
英文名稱
TASP 0277308
CAS
945725-50-8
分子式
C23H28Cl2N6O3S
分子量
539.48
MOL 文件
945725-50-8.mol
945725-50-8 結(jié)構(gòu)式
基本信息
英文別名
TASP 02773083,4-dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
3,4-dichloro-N-[(1R)-1-{4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-4H-1,2,4-triazol-3-yl}ethyl]benzenesulfonamide
物理化學(xué)性質(zhì)
沸點(diǎn)707.5±70.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件-10 to -25°C
溶解度Soluble to 5 mM in DMSO
酸度系數(shù)(pKa)7.90±0.50(Predicted)
形態(tài)powder
顏色white to beige
應(yīng)用領(lǐng)域
用途一
TASP0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP0277308 inhibited S1P- as well as VEGF-induced cellular responses, including migration and proliferation of human umbilical vein endothelial cells. Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo.