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931417-26-4

中文名稱 化合物 T10325
英文名稱 ANI-7
CAS 931417-26-4
更新日期 2023/03/20 15:41:25
分子式 C13H8Cl2N2
分子量 263.12
MOL 文件 931417-26-4.mol
931417-26-4 結(jié)構(gòu)式 931417-26-4 結(jié)構(gòu)式

基本信息

中文別名
化合物ANI-7
化合物 T10325
英文別名
ANI-7
ANI 7,ANI7

物理化學(xué)性質(zhì)

沸點(diǎn)443.0±45.0 °C(Predicted)
密度1.398±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 20.83 mg/mL (79.17 mM)
酸度系數(shù)(pKa)15.79±0.50(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
化合物 T10325價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-117102化合物 T10325
ANI-7
931417-26-45mg700元
2024/11/08HY-117102化合物 T10325
ANI-7
931417-26-410mM * 1mLin DMSO770元
2024/11/08HY-117102化合物 T10325
ANI-7
931417-26-410mg1200元

常見問題列表

生物活性
ANI-7 是一種 AhR 途徑的激活劑。ANI-7 抑制多種癌細(xì)胞的生長,并有選擇地抑制 MCF-7 乳腺癌細(xì)胞的生長,GI50 為 0.56 μM。ANI-7 通過激活 AhR 途徑誘導(dǎo) CYP1 代謝單加氧酶,并在敏感的乳腺癌細(xì)胞系中誘導(dǎo) DNA 損傷,檢查點(diǎn)激酶 (Chk2) 激活,S 期細(xì)胞周期停滯和細(xì)胞死亡。
靶點(diǎn)

Aryl Hydrocarbon Receptor

Chk2

體外研究

ANI-7 (2.5 μM; 24 hours; MCF10A and MDA-MB-468 cells) treatment induces significant S-phase and G2 + M-phase cell cycle arrest within 24 hours of treatment in MDA-MB-468 cells, and negligible effect in normal breast MCF10A cells.
ANI-7 (2 μM; 12-24 hours; MDA-MB-468 cells) treatment results in a significant increase in the content and phosphorylation of CHK2, and induces a significant increase in H2AX? in MDA-MB-468 cells, indicative of DNA double-strand damage.
Inhibition of the AhR pathway ameliorates the effects of ANI-7. ANI-7 activates XRE activity and expression of the AhR and CYP1 members.
Comparisons of the GI 50 values show that ANI-7 produces a GI 50 value of 0.38 μM in MCF-7 cells, whereas values of 3.0-42 μM are observed in cell lines from lung, colon, ovary, neuronal, glial, prostate, and pancreas. The only other tumor type that shows appreciable growth inhibition by ANI-7 is the A431 vulva cell line (GI 50 of 0.51μM).
ANI-7 potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells (GI 50 range of 0.16-0.38 μM), moderately inhibits the growth of BT20 and BT474 cells (GI50 range of 1-2 μM), and essentially fails to inhibit the growth of MDA-MB-231 and MCF10A cells (GI 50 range of 17-26 μM). Moreover, ANI-7 maintained its ability to inhibit the growth of drug-resistant cells (MCF-7/VP16: GI 50 of 0.21 μM).

Cell Cycle Analysis

Cell Line: MCF10A and MDA-MB-468 cells
Concentration: 2.5 μM
Incubation Time: 24 hours
Result: Induced significant S-phase and G2 + M-phase cell cycle arrest in MDA-MB-468 cells, and negligible effect in normal breast MCF10A cells.

Western Blot Analysis

Cell Line: MDA-MB-468 cells
Concentration: 2 μM
Incubation Time: 12 hours, 24 hours
Result: Resulted in a significant increase in the content and phosphorylation of CHK2 (25-fold increase),and induced a significant increase in H2AX? (3.5-fold increase).
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