915720-21-7
中文名稱
5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺
英文名稱
AZ-23
CAS
915720-21-7
分子式
C17H19ClFN7O
分子量
391.83
MOL 文件
915720-21-7.mol
更新日期
2023/08/30 13:34:13
915720-21-7 結(jié)構(gòu)式
基本信息
中文別名
5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺 英文別名
AZ-23AZ23
AZ-23
5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
(S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)596.1±60.0 °C(Predicted)
密度1.411
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:125.0(Max Conc. mg/mL);319.02(Max Conc. mM)
酸度系數(shù)(pKa)12.37±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-15590 | 5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺 AZ-23 | 915720-21-7 | 2mg | 1100元 |
| 2024/11/08 | HY-15590 | 5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺 AZ-23 | 915720-21-7 | 10mM * 1mLin DMSO | 1896元 |
| 2024/11/08 | HY-15590 | 5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-異丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺 AZ-23 | 915720-21-7 | 5mg | 2200元 |
常見(jiàn)問(wèn)題列表
生物活性
AZ-23是ATP-競(jìng)爭(zhēng)型，有口服活性的Trk激酶 A/B/C抑制劑，IC50值分別為2 nM (TrkA)，8 nM (TrkB)，24 nM (FGFR1)，52 nM (Flt3)，55 nM (Ret)，84 nM (MuSk)，99 nM (Lck)。靶點(diǎn)
|
TrkA 2 nM (IC 50 ) |
TrkB 8 nM (IC 50 ) |
體外研究
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.
體內(nèi)研究
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma.