903895-98-7
中文名稱
1-(4-氯苯基)-3-(5-異丙基-1-甲基-3-氧亞基-2-苯基-2,3-二氫-1H-吡唑-4-基)脲
英文名稱
1-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea
CAS
903895-98-7
分子式
C20H21ClN4O2
分子量
384.86
MOL 文件
903895-98-7.mol
更新日期
2024/12/31 09:16:46
903895-98-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T170051-(4-氯苯基)-3-(5-異丙基-1-甲基-3-氧亞基-2-苯基-2,3-二氫-1H-吡唑-4-基)脲
英文別名
TC-FPR 431-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea
N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Urea, N-(4-chlorophenyl)-N'-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-
1-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea(WXC04969)
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 1 mg/ml
形態(tài)結(jié)晶固體
顏色White to light yellow
常見問題列表
生物活性
FPR Agonist 43 (compound 43) 是有效的甲?；氖荏w 1 (FPR1) 和甲酰基肽受體 2 (FPR2)/ALX 雙重激動劑。靶點(diǎn)
FPR1, FPR2/ALX
體外研究
FPR Agonist 43 (10
-5
-10
7
nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells.
FPR Agonist 43 is also active in the GTPγ binding assay (IC
50
=207±51 nM).
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells.
Cell Viability Assay
| Cell Line: | Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors |
| Concentration: | 10 -5 , 10 -3 , 0.1, 10, 1000, 10 5 , 10 7 nM |
| Incubation Time: | |
| Result: | Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC 50 =11.6±1.9 nM). |