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894095-98-8

中文名稱 Β-D-葡萄糖醛酸-PNP-碳酸酯
英文名稱 (2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
CAS 894095-98-8
分子式 C45H43N3O18
分子量 913.832
MOL 文件 894095-98-8.mol
894095-98-8 結(jié)構(gòu)式 894095-98-8 結(jié)構(gòu)式

基本信息

中文別名
Β-D-葡萄糖醛酸-PNP-碳酸酯
三乙酸[(2S,3R,4S,5S,6S)-2-[2-[3-(FMOC-氨基)丙酰氨基]-4-[[[(4-硝基苯氧基)羰基]氧基]甲基]苯氧基]-6-(甲氧基羰基)四氫-2H-吡喃-3,4,5-三基]酯
英文別名
β-D-glucuronide-pNP-carbonate
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitroph
(2S,3R,4S,5S,6S)-2-[2-[3-(Fmoc-amino)propanamido]-4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenoxy]-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
9H-fluoren-9-ylmethyl ({3-[(2-{[(2S,3R,4S,5S,6S)-3,4,5-triacetoxy-6-(methoxycarbonyl)-3,4,5,6-tetrahydro-2H-pyran-2-yl]oxy}-5-[({[(4-nitrophenyl)oxy]carbonyl}oxy)methyl]phenyl)amino]-3-oxopropyl}amino)methanoate

物理化學(xué)性質(zhì)

形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
β-D-glucuronide-pNP-carbonate 是一種可降解 (cleavable) 的 ADC linker,可用于合成抗體偶聯(lián)藥物 (ADC)。
靶點(diǎn)

Cleavable

體外研究

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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