88979-61-7
中文名稱
巴佛洛霉素C 1
英文名稱
BAFILOMYCIN C1
CAS
88979-61-7
分子式
C39H60O12
分子量
720.89
MOL 文件
88979-61-7.mol
更新日期
2023/03/20 15:41:19
88979-61-7 結(jié)構(gòu)式
基本信息
中文別名
巴菲霉素C1巴弗洛霉素C1
巴伐洛霉素 C1
巴佛洛霉素C 1
英文別名
L-681110A1BAFILOMYCIN C1
Antibiotic L-681110A1
2-Demethyl-2-methoxy-24-methylhygrolidin
2-Butenedioic acid (2E)-, 1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl] ester
巴佛洛霉素C 1價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-130173 | 巴佛洛霉素C 1 Bafilomycin C1 | 88979-61-7 | 1mg | 1980元 |
| 2024/04/30 | HY-130173 | 巴佛洛霉素C 1 Bafilomycin C1 | 88979-61-7 | 5 mg | 9800元 |
| 2022/04/29 | HY-130173 | 巴佛洛霉素C 1 Bafilomycin C1 | 88979-61-7 | 500μg | 12000元 |
常見問題列表
生物活性
Bafilomycin C1 是從鏈霉菌中分離得到的大環(huán)內(nèi)酯類抗生素 (antibiotic)。Bafilomycin C1 是一種有效的、特異性的、可逆的 vacuolar-type H+-ATPases 抑制劑。Bafilomycin C1 抑制革蘭氏陽性菌 (bacteria) 和真菌 (fungi) 的生長。Bafilomycin C1 可誘導(dǎo)細(xì)胞凋亡 (apoptosis)，可用于肝細(xì)胞癌 (HCC) 的研究。體外研究
Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner.Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells.Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle.
Cell Viability Assay
| Cell Line: | SMMC7721 cell and HepG2 cell |
| Concentration: | 0.33 μM, 1.1 μM, and 3.3 μM for SMMC77211.1 μM, 3.3 μM, and 10.0 μM for HepG2 |
| Incubation Time: | 6 days |
| Result: | Retarded the cell growth. |
Western Blot Analysis
| Cell Line: | SMMC7721 cells |
| Concentration: | 3.3 μM |
| Incubation Time: | 24 hours |
| Result: | Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21. |
Apoptosis Analysis
| Cell Line: | SMMC7721 and HepG2 cells |
| Concentration: | 3.3 μM; 10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in SMMC7721 and HepG2 cells. |
體內(nèi)研究
Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model.
| Animal Model: | BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×10 6 cells/100 μL) |
| Dosage: | 0.2 mg/kg |
| Administration: | Subcutaneous injection; 20 days |
| Result: | Suppressed tumor growth of SMMC7721 tumor xenografts. |