88898-17-3
中文名稱
心鈉肽
英文名稱
ATRIAL NATRIURETIC FACTOR (1-28) (RAT)
CAS
88898-17-3
分子式
C128H205N45O39S2
分子量
3062.41
MOL 文件
88898-17-3.mol
更新日期
2024/11/01 22:01:48
88898-17-3 結(jié)構(gòu)式
基本信息
中文別名
心鈉肽心鈉素大鼠
心房利尿鈉因子
心房利尿肽因子(鼠)
英文別名
RANFRANP
ANF 1-28
ALPHA-RANP
ANP-(1-28)
RANF (1-28)
CARDIONATRIN
ANP 1-28, RAT
ANF (1-28), RAT
α-atriopeptin, rat
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
密度1.54±0.1 g/cm3(Predicted)
儲存條件-20°C
溶解度0.05 M acetic acid: 1 mg/mL, clear, colorless
溶解度在0.05M乙酸中溶解度：1 mg/mL，澄清，無色
形態(tài)Solid
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
序列H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH(Disulfide bridge: Cys7-Cys23)
常見問題列表
生物活性
Atrial Natriuretic Peptide (ANP) (1-28), rat 是心房利鈉肽 (ANP) 在大鼠中的主要循環(huán)形式，強效抑制血管緊張素 II (Ang II)-刺激的內(nèi)皮素-1 (endothelin-1) 分泌。靶點
Endothelin-1
體外研究
Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM.