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888486-23-5

中文名稱 H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)
英文名稱 H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)
CAS 888486-23-5
分子式 C40H64N14O16S2
分子量 1061.15
MOL 文件 888486-23-5.mol
更新日期 2024/10/29 11:49:39
888486-23-5 結(jié)構(gòu)式 888486-23-5 結(jié)構(gòu)式

基本信息

中文別名
細(xì)胞穿透肽 TRANSDERMAL PEPTIDE
英文別名
TD 1 (peptide)
Transdermal Peptide Disulfide
Transdermal Peptide (TD 1 peptide)
H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)
Glycine, L-alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinyl-, cyclic (2→10)-disulfide (9CI)
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)1728.7±65.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.57±0.10(Predicted)
序列H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH(Disulfide bond)

常見(jiàn)問(wèn)題列表

生物活性
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) 是由 11 個(gè)氨基酸組成的多肽,可以與 Na+/K+-ATPase beta-subunit (ATP1B1) 結(jié)合,主要與 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide 能夠增強(qiáng)一些大分子在皮膚中的傳遞。
體外研究

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin.

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