88847-89-6
中文名稱
8-OH-脫氧鳥嘌呤
英文名稱
8-OXO-2'-DEOXYGUANOSINE
CAS
88847-89-6
分子式
C10H13N5O5
分子量
283.24
MOL 文件
88847-89-6.mol
更新日期
2023/09/01 14:50:13
88847-89-6 結(jié)構(gòu)式
基本信息
中文別名
8-羥基脫氧鳥苷8-OH-脫氧鳥嘌呤
8-羥基-2-脫氧鳥苷
2'-脫氧-8-氧代鳥嘌呤
8-羥基-2'-脫氧鳥嘌呤
2'-脫氧-7,8-二氫-8-氧代鳥苷
英文別名
8-Oxodeoxyguanosine2-Amino-9-((2R,4S,5R)
-3H-purine-6,8(7H,9H)
8-hydroxydeoxyguanosine
8-OXO-2'-DEOXYGUANOSINE
2'-Deoxy-8-oxoguanosine
2'-Deoxy-8-oxo-D-guanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-oxo-7-hydrodeoxyguanosine
2'-Deoxy-8-hydroxyguanosine
所屬類別
生物化工：脫氧核苷酸及其類似物物理化學(xué)性質(zhì)
熔點(diǎn)217-220°C
密度2.25±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度溶于DMSO（高達(dá)10mg/ml）。
酸度系數(shù)(pKa)7.86±0.20(Predicted)
形態(tài)白色至類白色固體
顏色米白色
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲存1個月。
常見問題列表
生物活性
8-Hydroxy-2'-deoxyguanosine 是氧化應(yīng)激和致癌反應(yīng)的關(guān)鍵生物標(biāo)志物。靶點(diǎn)
|
Human Endogenous Metabolite
|
體外研究
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.