88377-68-8
中文名稱
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
英文名稱
ADRENORPHIN
CAS
88377-68-8
分子式
C44H69N15O9S
分子量
984.18
MOL 文件
88377-68-8.mol
更新日期
2024/12/16 11:45:47
88377-68-8 結(jié)構(gòu)式
基本信息
中文別名
YV-8-NH2受體激動劑多肽METORPHAMIDE
化合物ADRENORPHIN(3TFA)
英文別名
METORPHINADRENORPHIN
METORPHAMIDE
METORPHINAMIDE
Adrenorphin(3TFA)
adrenorphin amide
ADRENORPHIN (BOVINE)
Adrenorphin (metorphamide)
Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
PROENKEPHALIN (206-213) (BOVINE)
物理化學(xué)性質(zhì)
密度1.42±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
酸度系數(shù)(pKa)9.97±0.15(Predicted)
形態(tài)固體
顏色White to off-white
序列H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
常見問題列表
生物活性
Adrenorphin 是一種阿片八肽，為 μ-opioid 受體激動劑，Ki 值為 12 nM。靶點
Ki: 12 nM (μ-opioid receptor)
體外研究
Adrenorphin (Metorphamide) is a opioid octapeptide from bovine brain, acts as a potent agonist of μ-opioid receptor, with K i of 12 nM. The binding ratios of K i for μ-opioid receptor/K i for δ-opioid receptor of 0.04 and of K i for μ-opioid receptor/K i for κ-opioid receptor of 0.46. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with an IC 50 of 1.1 μM.