88070-98-8
中文名稱
BROMOENOL LACTONE
英文名稱
BROMOENOL LACTONE
CAS
88070-98-8
分子式
C16H13BrO2
分子量
317.18
MOL 文件
88070-98-8.mol
88070-98-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14829 英文別名
BELHELSS
HALOENOL LACTONE
BROMOENOL LACTONE
(6E)-Bromoenol lactone
Bromoenol lactone (BEL)
Bromoenol Lactone Solution
HALOENOL LACTONE SUICIDE SUBSTRATE
(6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
E-6-(BROMOETHYLENE)TETRAHYDRO-3-(1-NAPHTHYL)-2H-PYRAN-2-ONE
物理化學(xué)性質(zhì)
熔點(diǎn)103-106℃
沸點(diǎn)467.0±45.0 °C(Predicted)
密度1.538±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble
形態(tài)白色固體。
顏色White to yellow
常見問題列表
生物活性
Bromoenol lactone ((6E)-Bromoenol lactone) 是一種不可逆的選擇性的和有效的鈣依賴性磷脂酶 A2 (iPLA2β) 抑制劑，其 IC50 值約為 7 μM，可抑制抗原刺激的肥大細(xì)胞胞吐作用，而不會阻止 Ca2+ 的大量涌入。靶點(diǎn)
|
PLA2 7 μM (IC 50 ) |
體外研究
In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca 2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca 2+ ionophore A23187, which passively transports Ca 2+ down a concentration gradient and also in permeabilised mast cells where Ca 2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca 2+ signalling, both the release from internal stores and sustained elevation due to Ca 2+ influx.