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87218-84-6

中文名稱 黑色素聚集激素肽
英文名稱 MELANIN CONCENTRATING HORMONE, SALMON
CAS 87218-84-6
分子式 C89H139N27O24S4
分子量 2099.5
MOL 文件 87218-84-6.mol
更新日期 2024/11/01 22:01:48
87218-84-6 結(jié)構(gòu)式 87218-84-6 結(jié)構(gòu)式

基本信息

中文別名
黑素濃集素
鮭魚黑色素聚集激素
黑色素聚集激酶素(MCH
英文別名
MCH (SALMON)
MELANIN CONCENTRATING HORMONE
Salmon melanin-concentrating hormone
MELANIN CONCENTRATING HORMONE, SALMON
Melanin concentrating hormone salmon, ≥90%
MCH (salMon) Melanin-Concentrating HorMone (salMon)
ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL
Asp-Thr-Met-Arg-c[Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys]-Trp-Glu-Val
H-ASP-THR-MET-ARG-CYS-MET-VAL-GLY-ARG-VAL-TYR-ARG-PRO-CYS-TRP-GLU-VAL-OH
REF DUPL: Asp-Thr-Met-Arg-c[Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys]-Trp-Glu-Val

物理化學性質(zhì)

密度1.52±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度溶于二甲基亞砜
形態(tài)固體
顏色White to off-white

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany3

常見問題列表

生物活性
Melanin Concentrating Hormone, salmon是最初在硬骨魚的垂體中發(fā)現(xiàn)的19個氨基酸組成的神經(jīng)肽，它調(diào)節(jié)食物攝入，能量平衡，睡眠狀態(tài)和心血管系統(tǒng)。 Melanin-concentrating hormone是 SLC-1/GPR24 和 MCHR2 的配體。
靶點

SLC-1/GPR24, MCHR2

體外研究

An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.

體內(nèi)研究

Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.

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