863971-44-2
中文名稱(chēng)
FMOC-3AA-OH
英文名稱(chēng)
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
CAS
863971-44-2
分子式
C36H51N3O7
分子量
637.81
MOL 文件
863971-44-2.mol
更新日期
2025/02/09 17:13:28
863971-44-2 結(jié)構(gòu)式
基本信息
中文別名
一甲基奧瑞他汀中間體10化合物FMOC-3VVD-OH
(5S,9S,11S,12R)-11 - ((S) - 仲丁基)-1-(9H-芴-9-基)-5,9-
4-[(2-{2-[(9H-氟-9-基甲氧基羰基)-甲基氨基]-3-甲基-丁?；被鶀-3-甲基-丁?；?-甲基氨基]-3-甲氧基-5-甲基庚酸
(5S,8S,11S,12R)-11-((S)-仲丁基)-1-(9H-芴-9-基)-5,9-二異丙基-12-甲氧基-4,10-二甲基 3,6,8-三氧代-2-氧雜-4,7,10-三氮雜十四烷-14-酸
英文別名
FMOC-3AA-OHFmoc-3AA-orl
Fmoc-3vvd-OH
Tripeptide (MMAE-3)
Fmoc-Meval-val-dolaisoleucine-OH
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L- valinamide
L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-
(5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
所屬類(lèi)別
生物：蛋白與多肽物理化學(xué)性質(zhì)
沸點(diǎn)793.0±60.0 °C(Predicted)
密度1.144±0.06 g/cm3(Predicted)
溶解度DMSO: ≥ 37 mg/mL (58.01 mM)
酸度系數(shù)(pKa)4.08±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Water: < 0.1 mg/mL (insoluble)
InChIKeyJDMOCVJBADMSJP-FCUBIXSHSA-N
SMILESC(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C
常見(jiàn)問(wèn)題列表
用途
Fmoc-3VVD-OH是可裂解的ADC接頭，用于抗體-藥物偶聯(lián)物（ADC）的合成。體內(nèi)研究
ADC由通過(guò)ADC接頭連接ADC細(xì)胞毒素的抗體組成。生物活性
Fmoc-3VVD-OH 是一種可降解 (non-cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。靶點(diǎn)
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Cleavable
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體外研究
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.