863774-58-7

基本信息
EG5抑制劑(DIMETHYLENASTRON)
2,3,4,6,7,8-六氫-4-(3-羥基苯基)-7,7-二甲基-2-硫代-5(1H)-喹唑啉酮
Dimethylenastron
Eg5 Inhibitor III
Eg5 Inhibitor III(Dimethylenastron)
Dimethylenastron - Eg5 inhibitor III
Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem
2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
4-(3-Hydroxyphenyl)-7,7-dimethyl-2-thioxo-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one
5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/02/08 | HY-19944 | 2,3,4,6,7,8-六氫-4-(3-羥基苯基)-7,7-二甲基-2-硫代-5(1H)-喹唑啉酮 Dimethylenastron | 863774-58-7 | 1 mg | 320元 |
2025/02/08 | HY-19944 | 2,3,4,6,7,8-六氫-4-(3-羥基苯基)-7,7-二甲基-2-硫代-5(1H)-喹唑啉酮 Dimethylenastron | 863774-58-7 | 5mg | 700元 |
2025/02/08 | HY-19944 | 2,3,4,6,7,8-六氫-4-(3-羥基苯基)-7,7-二甲基-2-硫代-5(1H)-喹唑啉酮 Dimethylenastron | 863774-58-7 | 10mM * 1mLin DMSO | 770元 |
常見問題列表
Target | Value |
KSP
(Cell-free assay) | 200 nM |
Dimethylenastron is a potent Eg5 inhibitor, with an IC 50 of 200 nM. Dimethylenastron exhibits no inhibition of five other kinesin subfamilies (kinesin 1/4/7/10 and one ungrouped-originating from 4 different organisms). Dimethylenastron (0.5, 1 μM) causes accumulation of cells in G2/M in HeLa cells. Dimethylenastron (3 and 10 μM) concentration-dependently suppresses the migratory ability of the cancer cells in PANC1 pancreatic cancer cells after treatment for 24 h, but does not inhibit the proliferation of cancer cells at 24 h until 72 h. Dimethylenastron also reduces invasion ability of the cancer cells.
Dimethylenastron (1.0 μmol) induces a milder scarring but the length of bleb survival is not significantly prolonged compared with the control group. Dimethylenastron (1.0 μmol) reveals a markedly reduced ratio of intraocular pressure and a milder, but not obviously reduced, subconjunctival fibrotic reaction in the rabbits treated with glaucoma filtration surgery.