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861214-33-7

中文名稱 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
英文名稱 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
CAS 861214-33-7
分子式 C16H10FN3O2
分子量 295.27
MOL 文件 861214-33-7.mol
更新日期 2023/03/20 15:41:21
861214-33-7 結(jié)構(gòu)式 861214-33-7 結(jié)構(gòu)式

基本信息

中文別名
化合物5'-FLUOROINDIRUBINOXIME
5'-氟-3-(肟基)-[2,3'-雙吲哚亞基]-2'-酮
英文別名
5'-FIO
-Fluoroindirubinoxime
5'-Fluoroindirubinoxime
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-

物理化學(xué)性質(zhì)

沸點528.3±50.0 °C(Predicted)
密度1.57±0.1 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic)
酸度系數(shù)(pKa)8.48±0.20(Predicted)
形態(tài)粉末
顏色Light brown to black

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-1034645'-Fluoroindirubinoxime861214-33-71 mg678元
2025/02/08HY-1034645'-Fluoroindirubinoxime861214-33-75 mg1600元
2025/02/08HY-1034645'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
5'-Fluoroindirubinoxime		861214-33-710mg2414元

常見問題列表

生物活性
5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制劑，其IC50 值為15 nM。
靶點

15 nM (FLT3).

體外研究

5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC 50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC 50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.

體內(nèi)研究

5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.

Animal Model: Rat tumor model based RK3E-ras cells.
Dosage: S.C..
Administration: 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.
Result: Effectively inhibited tumor growth.
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