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85916-47-8

中文名稱 鈣抑肽
英文名稱 KATACALCIN
CAS 85916-47-8
分子式 C97H154N34O36S2
分子量 2436.62
MOL 文件 85916-47-8.mol
更新日期 2024/12/23 10:30:27
85916-47-8 結(jié)構(gòu)式 85916-47-8 結(jié)構(gòu)式

基本信息

中文別名
鈣抑肽
KATACALCIN肽
英文別名
PDN-21
KATACALCIN
PDN-21 (HUMAN)
C-PROCALCITONIN
KATACALCIN (HUMAN)
KATACALCIN USP/EP/BP
DMSSDLERDHRPHVSMPQNAN
C-PROCALCITONIN (HUMAN)
Katacalcin (human)(9CI)
Katacalcin, PDN-21, C-Procalcitonin (huMan)

物理化學(xué)性質(zhì)

密度1.62±0.1 g/cm3(Predicted)
儲(chǔ)存條件-15°C

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335

常見問題列表

生物活性
Katacalcin (PDN 21) 是一種有效的具有降低血鈣效應(yīng)的多肽激素。
體外研究

Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14 + peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14 + PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14 + PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14 + PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.

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