85916-47-8
基本信息
KATACALCIN肽
KATACALCIN
PDN-21 (HUMAN)
C-PROCALCITONIN
KATACALCIN (HUMAN)
KATACALCIN USP/EP/BP
DMSSDLERDHRPHVSMPQNAN
C-PROCALCITONIN (HUMAN)
Katacalcin (human)(9CI)
Katacalcin, PDN-21, C-Procalcitonin (huMan)
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2025/02/08 | HY-P0149 | 鈣抑肽 Katacalcin | 85916-47-8 | 1 mg | 800元 |
2025/02/08 | HY-P0149 | 鈣抑肽 Katacalcin | 85916-47-8 | 5 mg | 2000元 |
2025/02/08 | HY-P0149 | 鈣抑肽 Katacalcin | 85916-47-8 | 10 mg | 3200元 |
常見問題列表
Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14 + peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14 + PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14 + PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14 + PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.