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856692-39-2

中文名稱 化合物 CEP-14083
英文名稱 Urea, N'-(4,5,6,11,12,13-hexahydro-2-Methyl-4-oxo-11-propyl-2H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-8-yl)-N-Methyl-N-phenyl-
CAS 856692-39-2
分子式 C31H30N6O2
分子量 518.609
MOL 文件 856692-39-2.mol
856692-39-2 結構式 856692-39-2 結構式

基本信息

中文別名
化合物 CEP-14083
英文別名
CEP-14083
DRYABXKGCXCACQ-UHFFFAOYSA-N
Urea, N'-(4,5,6,11,12,13-hexahydro-2-Methyl-4-oxo-11-propyl-2H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-8-yl)-N-Methyl-N-phenyl-

物理化學性質

沸點833.7±65.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.95±0.20(Predicted)

應用領域

用途一
CEP-14083 is a potent ALK inhibitor that has shown activity in an NPM/ALK?–carrying T-cell lymphoma in vitro study. Presumably, this compound binds to the hinge region of the kinase in an ATP-competitive manner. CEP-14083 displays a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L). Further, CEP-14083 is also able to inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed that, via NPM/ALK TK inhibition, it could control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. CEP-14083 has shown preclinical activity in both cell lines and animal models harboring ALK alteration.
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