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850559-53-4

中文名稱 化合物 T26872
英文名稱 BMVC 4
CAS 850559-53-4
分子式 C26H23IN5+
分子量 532.41
MOL 文件 850559-53-4.mol
850559-53-4 結(jié)構(gòu)式 850559-53-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T26872
英文別名
BMVC4
BMVC-4
BMVC 4

應(yīng)用領(lǐng)域

用途一
BMVC4 is a G-quadruplex stabilizer. MVC4-treated cancer cells showed typical senescence phenotypes. BMVC4 induced senescence in both ALT and telomerase-overexpressing cells, suggesting that telomere shortening through telomerase inhibition might not be the cause for senescence. BMVC4 induced senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity. BMVC4 has the potential to be developed as a chemotherapeutic agent against both telomerase positive and ALT cancer cells.
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