849214-04-6
中文名稱
C-GPAP
英文名稱
c-GpAp
CAS
849214-04-6
分子式
C20H24N10O13P2
分子量
674.41
MOL 文件
849214-04-6.mol
更新日期
2024/11/18 16:34:38
849214-04-6 結(jié)構(gòu)式
基本信息
中文別名
CGAMP銨鹽CGAMP 鈉鹽
英文別名
cGAMPc-GpAp
di-GAMP
di-cGAMP
3'3'-cGAMP
Cyclic GMP-AMP
cGAMP ammonium salt
cGAMP (Cyclic GMP-AMP
c-(ApGp) / 3'3'-cGAMP
RFCBNSCSPXMEBK-XRIIRFCZSA-N
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)1159.9±75.0 °C(Predicted)
密度2.61±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
酸度系數(shù)(pKa)0.96±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
水溶解性Water : 20 mg/mL (29.66 mM)
常見問題列表
生物活性
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活內(nèi)質(zhì)網(wǎng)(ER)內(nèi)源性受體 stimulator of interferon genes (STING) ，從而誘導(dǎo)抗病毒狀態(tài)和I型IFN的分泌。靶點(diǎn)
| Target | Value |
|
STING
() |
體外研究
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
體內(nèi)研究
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old |
| Dosage: | 5 μg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |