83602-39-5
83602-39-5 結(jié)構(gòu)式
基本信息
環(huán)胞霉素B
環(huán)孢霉素H
環(huán)孢菌素 H
環(huán)孢菌素雜質(zhì)H
環(huán)孢素H, 來源于小單孢菌
環(huán)[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-纈氨酰-3-羥基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-2-氨基丁酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-纈氨酰-N-甲基-L-亮氨酰]
CYCLOSPORIN H
Cyclosporin H, >=95%
Cyclosporine IMpurity-H
5-(N-Methyl-D-valine)cyclosporin A
Cyclosporin H, froM MicroMonospora
5-(N-Methyl-D-valine)cyclosporine A
Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl]
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/05 | HY-P1122 | 環(huán)孢菌素 H Cyclosporin H | 83602-39-5 | 1 mg | 1236元 |
| 2025/02/05 | HY-P1122 | 環(huán)孢菌素 H Cyclosporin H | 83602-39-5 | 5mg | 3400元 |
| 2025/02/05 | HY-P1122 | 環(huán)孢菌素 H Cyclosporin H | 83602-39-5 | 10mg | 5450元 |
常見問題列表
The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a K i of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a K i of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca 2+ concentration ([Ca 2+ ]i), O2- formation, and beta-glucuronidase release with K i values of 0.08, 0.24, and 0.45 μM, respectively.
Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel).