828288-98-8
828288-98-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度2.14±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 100 mg/mL (216.73 mM)
酸度系數(shù)(pKa)0.90±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
828288-98-8價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/05 | HY-112860 | Asp-AMS | 828288-98-8 | 1 mg | 2045元 |
| 2025/02/05 | HY-112860 | 828288-98-8 Asp-AMS | 828288-98-8 | 5mg | 4500元 |
| 2024/08/19 | HY-112860 | 828288-98-8 Asp-AMS | 828288-98-8 | 10mg | 7000元 |
常見問題列表
生物活性
Asp-AMS是天冬氨酸腺苷酸的一個類似物，是 aspartyl-tRNA 合成酶 (aspartyl-tRNA synthetase) 的一個抑制劑，也是線粒體酶 (mitochondrial enzyme) 的強效競爭性抑制劑。靶點
Aspartyl-tRNA synthetase, Mitochondrial enzyme .
體外研究
Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with K i in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with K i values in the nanomolar range, with a stronger effect on bacterial AspRSs ( E. coli and P. aeruginosa ) than on human cytosolic AspRS.