817204-33-4
817204-33-4 結(jié)構(gòu)式
基本信息
2'-去氧-2'-氟-2'-C-甲基胞苷
2'-脫氧-2'-氟-2'-C-甲基胞苷
2'-去氧-2'-氟-2'-C-甲基胞苷/PSI6130
2'-脫氧-2'-氟-2'-C-甲基胞苷 PSI 6130
4-氨基-1-((2R,3R,4R,5R)-3-氟-4-羥基-5-(羥基甲基)-3-甲基四氫呋喃-2-基)嘧啶-2(1H)-酮
CS-1995
PSI 6130
PSI-6130
PSI 6130
PSI-6130
R 1656
PSI 6130
2'-Deoxy-2'-F-2'-C-methylcytidine
2'-deoxy-2'-fluoro-2'-C-methylcytidin
2'-deoxy-2'-fluoro-2'-C-methylcytidine
R 1656
R-1656
R1656
PSI6130
PSI 6130
(2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130 | 817204-33-4 | 2mg | 887元 |
| 2024/08/19 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130 | 817204-33-4 | 10mM * 1mLin DMSO | 1265元 |
| 2024/08/19 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130 | 817204-33-4 | 5mg | 1597元 |
常見(jiàn)問(wèn)題列表
IC50: 0.6 μM (HCV replication)
PSI-6130 exhibits potent and specific inhibitory activity against HCV RNA replication mediated by the NS5B polymerase. Both PSI-6130 inhibit HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with mean EC 50 values of 0.51 and 0.30 μM, respectively. PSI-6130 inhibits 40% human serum with EC 50 of 0.51 μM. PSI-6130 inhibits HCV replication with a mean IC 50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC 50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC 50 of 0.13 μM and K i of 0.023 μM.