804475-66-9
中文名稱
替莫瑞林
英文名稱
Unii-mqg94m5eeo
CAS
804475-66-9
分子式
C221H366N72O67S
分子量
5135.78
MOL 文件
804475-66-9.mol
更新日期
2024/03/25 08:08:49
804475-66-9 結(jié)構(gòu)式
基本信息
英文別名
TesamorelinTh-9507
Th 9507
Unii-mqg94m5eeo
High Pure Peptides Th9507 Tesamorelin Powder 2mg/Vial
應(yīng)用領(lǐng)域
用途一
Tesamorelin acetate is an analog of growth hormone-releasing hormone
(GHRH) that was approved in the United States in 2010 for treatment of
lipodystrophy in HIV patients.
Tesomorelin is an analog of GHRH. GHRH stimulates the synthesis
and release of GH. In the pituitary, GH is secreted in a pulsatile manner.
GH control is regulated by somatostatin and the negative feedback regulator,
IGF-1. Direct administration of GH to patients with lipodystrophy
decreases VAT but has associated side effects such as fluid retention and
joint swelling. Because of the side effects associated with direct GH
administration, GHRH represents a attractive mechanism for increasing
GH levels. Tesomorelin is an analog of GHRH in which the N-terminal
amino acid, Tyr, is amidated with a trans-3-hexenoyl group. Capping of
the N-terminus protects GHRH from cleavage by DPP-4. Tesomorelin
demonstrates enhanced stability compared with GHRH in animal models.