79944-56-2
中文名稱
鹽酸咪唑克生
英文名稱
IDAZOXAN HYDROCHLORIDE
CAS
79944-56-2
分子式
C11H13ClN2O2
分子量
240.69
MOL 文件
79944-56-2.mol
更新日期
2025/02/05 09:06:04
79944-56-2 結(jié)構(gòu)式
基本信息
中文別名
鹽酸咪唑克生咪唑克生鹽酸鹽
英文別名
RX 781094AIdazoxanHCl
IDAZOXAN HYDROCHLORIDE
(+/-)-Idazoxan Monohydrochloride
2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)207-208°
儲(chǔ)存條件Store at RT
溶解度H2O: 300 mg/mL
形態(tài)Powder
顏色White to off-white
水溶解性Soluble to 100 mM in water
穩(wěn)定性Hygroscopic
鹽酸咪唑克生價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-14561A | 鹽酸咪唑克生 Idazoxan hydrochloride | 79944-56-2 | 1 mg | 209元 |
| 2025/02/08 | HY-14561A | 鹽酸咪唑克生 Idazoxan hydrochloride | 79944-56-2 | 5mg | 500元 |
| 2025/02/08 | HY-14561A | 鹽酸咪唑克生 Idazoxan hydrochloride | 79944-56-2 | 10mM * 1mLin DMSO | 553元 |
常見問題列表
生物活性
鹽酸咪唑克生(RX 781094 hydrochloride) 是一種 α2-腎上腺素受體拮抗劑，也是咪唑啉受體 (IRs) 拮抗劑，可競(jìng)爭(zhēng)性拮抗唑啉樣藥物 (IMs) 的中樞性降壓作用。其還可改善帕金森氏病，L-DOPA 引起的運(yùn)動(dòng)障礙和實(shí)驗(yàn)性帕金森病的運(yùn)動(dòng)癥狀。
靶點(diǎn)
α 2 -adrenoceptor; Imidazoline receptors (IRs)
體內(nèi)研究
Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED 50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol.
| Animal Model: | Male CD-COBS rats injected with 1?mg/kg haloperidol |
| Dosage: | 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0?mg/kg |
| Administration: | Subcutaneous injection; for 1 hour |
| Result: | Potently reversed haloperidol-induced catalepsy with an ED 50 of 0.25?mg/kg. |