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79756-69-7

中文名稱 TPI1;TPI 1
英文名稱 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
CAS 79756-69-7
分子式 C12H6Cl2O2
分子量 253.08
MOL 文件 79756-69-7.mol
更新日期 2024/10/22 09:47:20
79756-69-7 結構式 79756-69-7 結構式

基本信息

中文別名
TPI-1游離態(tài)
英文別名
TPI-1
TPI1
TPI 1
2-(2,5-Dichlorophenyl)-1,4-benzoquinone
Recombinant Human TIM/TPI1 Protein, His Tag
2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-
所屬類別
生物化工:激動劑抑制劑

物理化學性質

儲存條件Sealed in dry,2-8°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
形態(tài)結晶固體
顏色White to yellow

安全數據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
海關編碼2914698090

常見問題列表

生物活性
TPI-1 (Tyrosine Phosphatase Inhibitor 1)是一種有效的 SHP-1 抑制劑,對于重組SHP-1的IC50為40 nM。TPI-1具有抗癌的活性。
靶點
TargetValue
SHP-1
(Cell-free assay)
40 nM
體外研究

SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ + cells in human peripheral blood.

體內研究

TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.

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