78950-78-4
78950-78-4 結(jié)構(gòu)式
基本信息
7-(dipropylamino)tetralin-1-ol
2-(Dipropylamino)tetralin-8-ol
8-Hydroxy-2-(di-n-propylamino)tetralin
S(-)-8-Hydroxy-DPAT hydrobromide solid
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol
(+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide
1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
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5-HT 1A Receptor 8.19 (pIC 50 ) |
5-HT 7 Receptor 466 nM (Ki) |
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC 50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC 50 , 5.42), 5-HT (pIC 50 <5). 8-OH-DPAT has high affinity at 5-HT7 with a K i of 466 nM, and does not bind to 5-HT6 or 5-HT4.
8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice.