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78299-79-3

中文名稱 2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo(1,2-a)indazolium
英文名稱 2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo(1,2-a)indazolium
CAS 78299-79-3
MOL 文件 78299-79-3.mol
78299-79-3 結(jié)構(gòu)式 78299-79-3 結(jié)構(gòu)式

基本信息

中文別名
化合物 T19322
英文別名
FKK
2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo(1,2-a)indazolium

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜

安全數(shù)據(jù)

毒性LD50 oral in rat: 1380mg/kg

常見問題列表

生物活性
FKK 是一種吲唑衍生物,也是一種新型支氣管擴張劑。
體內(nèi)研究

FKK is an indazole derivative and also a novel bronchodilator. FKK (0.1 to 3.0 mg/kg, i.v.) slightly increases respiratory frequency, left ventricular (LV) dp/dt max and myocardial contractile force. A slight increase followed by a decrease is observed in systemic blood pressure and LV systolic pressure. FKK causes direct vasodilation in the coronary, mesenteric and femoral vasculatures, but has no effect on the renal vasculature. It is particularly pertinent that FKK (30 mg/kg, i.d., enough to cause marked bronchodilation), unlike aminophylline (30 mg/kg, i.d.), does not significantly influence the cardiovascular system.

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