76631-46-4
中文名稱
地托咪定
英文名稱
4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE
CAS
76631-46-4
分子式
C12H14N2
分子量
186.25
MOL 文件
76631-46-4.mol
更新日期
2024/06/25 17:15:56
76631-46-4 結(jié)構(gòu)式
基本信息
中文別名
地拖咪啶地托咪定
美托咪定雜質(zhì)26
右美托嘧啶雜質(zhì)D
美托咪定雜質(zhì)12
4-(2,3-二甲芐基)-1H-咪唑
右美托嘧啶雜質(zhì)D
4-(2,3-二甲芐基)-1H-咪唑
英文別名
Detomidinadetomidine
Detomidinum
Detomidine [inn:ban]
Detomidinum [inn-latin]
Detomidina [inn-spanish]
90038-01-0 (Monohydrochloride)
4-(2,3-Dimethylbenzyl)imidazol
4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE
5-[(2,3-DiMethylphenyl)Methyl]iMidazole
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)114-116°
沸點(diǎn)386.5±11.0 °C(Predicted)
密度1.077±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于氯仿（少許）、甲醇（少許）
酸度系數(shù)(pKa)14.44±0.10(Predicted)
形態(tài)固體
顏色白色至灰白色
常見(jiàn)問(wèn)題列表
生物活性
Detomidine 是一種咪唑衍生物，是一種有效的 α2-腎上腺素能 (α2-adrenergic) 激動(dòng)劑。Detomidine 產(chǎn)生劑量依賴性的鎮(zhèn)靜和鎮(zhèn)痛作用。體外研究
Currently, detomidine is only licenced for use in horses. Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.