76541-72-5
76541-72-5 結(jié)構(gòu)式
基本信息
米福貝特
MIFOBATE
Clenicor
claniclor
SR-202 >=98% (HPLC), crystalline
Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE
[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate
Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
phosphoricacid,(4-chlorophenyl)(dimethoxyphosphinyl)methyldimethylester
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100277 | 米福貝特 Mifobate | 76541-72-5 | 1mg | 880元 |
| 2024/11/08 | HY-100277 | 米福貝特 Mifobate | 76541-72-5 | 5mg | 2500元 |
| 2024/11/08 | HY-100277 | 米福貝特 Mifobate | 76541-72-5 | 10mM * 1mLin DMSO | 2750元 |
常見問題列表
|
PPARγ 140 μM (IC 50 ) |
Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days.
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX).
Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice
| Animal Model: | Eight-week-old male ob/ob mice |
| Dosage: | 400 mg/kg |
| Administration: | Feed (food admixture maintained for 20 days) |
| Result: | Prevented the time-dependent increase in glucose concentrations. |