764-22-7
中文名稱
D-赤式-C 18 - 二氫-D-神經(jīng)鞘氨醇
英文名稱
D-erythro-C18-Dihydro-D-sphingosine
CAS
764-22-7
分子式
C18H39NO2
分子量
301.51
MOL 文件
764-22-7.mol
764-22-7 結(jié)構(gòu)式
基本信息
中文別名
D-赤式-C 18 - 二氫-D-神經(jīng)鞘氨醇 英文別名
(2S,3R)-SPC-102860
SPHINGANINE
Sphinganine (d18:0)
D-erythro-sphinganine
Dihydro-D-erythro-Sphingosine
D-ERYTHRO-DIHYDRO-D-SPHINGOSINE
(2S,3R)-2-aminooctadecane-1,3-diol
D-erythro-C18-Dihydro-D-sphingosine
(2S,3R)-2-azanyloctadecane-1,3-diol
所屬類別
生物化工：生化試劑物理化學(xué)性質(zhì)
熔點(diǎn)70-72°C
沸點(diǎn)446.2±25.0 °C(Predicted)
密度0.927±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度在DMSO中的溶解度為25mg/mL（溫?zé)幔?/div>
酸度系數(shù)(pKa)12.57±0.45(Predicted)
形態(tài)白色至類白色固體
顏色白色
穩(wěn)定性可在-20°下的DMSO或乙醇溶液保存長(zhǎng)達(dá)1個(gè)月。
常見問題列表
生物活性
D-Erythro-dihydrosphingosin 直接抑制細(xì)胞溶質(zhì)中的磷脂酶 A2α (cPLA2α) 活性。靶點(diǎn)
|
Human Endogenous Metabolite
|
體外研究
D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na 3 VO 4 -, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [ 3 H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA 2 α activity.
"764-22-7"
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