75704-24-4
中文名稱
WAY 161503鹽酸鹽
英文名稱
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
CAS
75704-24-4
分子式
C11H11Cl2N3O
分子量
272.13
MOL 文件
75704-24-4.mol
75704-24-4 結(jié)構(gòu)式
基本信息
中文別名
WAY 161503鹽酸鹽 英文別名
WAY 161503WAY 161503 HYDROCHLORIDE
1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-
8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)513.9±50.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
儲(chǔ)存條件Desiccate at RT
溶解度DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
酸度系數(shù)(pKa)12.09±0.20(Predicted)
形態(tài)結(jié)晶固體
顏色Off-white to light yellow
常見(jiàn)問(wèn)題列表
用途
WAY 161503鹽酸鹽是一種有效的、選擇性的、高親和力的 5-HT2C 受體激動(dòng)劑，具有抗肥胖和抗抑郁的作用。
靶點(diǎn)
|
5-HT 2C Receptor 4 nM (Ki) |
5-HT 2C Receptor 12 nM (EC 50 ) |
體內(nèi)研究
(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT 2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT 2A KO mice.
| Animal Model: | Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) |
| Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT 2C/2B antagonist SER-082. |