72596-74-8
72596-74-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28348 英文別名
PD 404,1823,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
物理化學(xué)性質(zhì)
沸點(diǎn)366.8±25.0 °C(Predicted)
密度1.43±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO: ≥22 mg/mL, soluble
酸度系數(shù)(pKa)6.27±0.20(Predicted)
形態(tài)powder
顏色Light yellow to yellow
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說(shuō)明26-36
WGK Germany3
常見(jiàn)問(wèn)題列表
生物活性
PD 404182 是一種有效的、競(jìng)爭(zhēng)性的人類二甲基精氨酸二甲基氨基水解酶 1 (DDAH1) 抑制劑，IC50 值為 9 μM。PD 404182 在體外表現(xiàn)出抗血管生成和抗病毒活性。靶點(diǎn)
IC50: 9 μM (DDAH1)
體外研究
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC
50
of 1 μM.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD
4+
T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
Cell Viability Assay
| Cell Line: | Human dermal microvascular endothelial cells (ECs) |
| Concentration: | 10-300 μM |
| Incubation Time: | 24 hours |
| Result: | Did not induce cytotoxicity. |