72296-47-0
中文名稱(chēng)
ApovincaMinic Acid Hydrochloride Salt
英文名稱(chēng)
ApovincaMinic Acid Hydrochloride Salt
CAS
72296-47-0
分子式
C20H23ClN2O2
分子量
358.87
MOL 文件
72296-47-0.mol
72296-47-0 結(jié)構(gòu)式
基本信息
英文別名
Vinpocetine Carboxylic Acid HClApovincaMinic Acid Hydrochloride Salt
Vinpocetine Carboxylic Acid HCl (Apovincaminic Acid HCl)
物理化學(xué)性質(zhì)
熔點(diǎn)>236°C (dec.)
儲(chǔ)存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度DMSO（微溶）、甲醇（微溶）、水（微溶）
形態(tài)固體
顏色白色
穩(wěn)定性吸濕性
常見(jiàn)問(wèn)題列表
生物活性
Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一種具有口服活性和可透過(guò)血腦屏障的主要活性代謝產(chǎn)物。Apovincaminic acid hydrochloride salt 具有神經(jīng)保護(hù)作用。體內(nèi)研究
Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation.
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats.
| Animal Model: | Male Harlan‐Wistar rats (300-400 g) are injected NMDA |
| Dosage: | 10 mg/kg |
| Administration: | I.p. twice daily for 4 days |
| Result: |
Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation. |