72296-47-0
中文名稱
ApovincaMinic Acid Hydrochloride Salt
英文名稱
ApovincaMinic Acid Hydrochloride Salt
CAS
72296-47-0
分子式
C20H23ClN2O2
分子量
358.87
MOL 文件
72296-47-0.mol
72296-47-0 結構式
基本信息
英文別名
Vinpocetine Carboxylic Acid HClApovincaMinic Acid Hydrochloride Salt
Vinpocetine Carboxylic Acid HCl (Apovincaminic Acid HCl)
物理化學性質
熔點>236°C (dec.)
儲存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度DMSO（微溶）、甲醇（微溶）、水（微溶）
形態(tài)固體
顏色白色
穩(wěn)定性吸濕性
ApovincaMinic Acid Hydrochloride Salt價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/05 | HY-133813A | Apovincaminic acid hydrochloride salt | 72296-47-0 | 1 mg | 500元 |
| 2025/02/05 | HY-133813A | ApovincaMinic Acid Hydrochloride Salt Apovincaminic acid hydrochloride salt | 72296-47-0 | 5mg | 1100元 |
| 2025/02/05 | HY-133813A | ApovincaMinic Acid Hydrochloride Salt Apovincaminic acid hydrochloride salt | 72296-47-0 | 10 mM * 1 mLin DMSO | 1210元 |
常見問題列表
生物活性
Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一種具有口服活性和可透過血腦屏障的主要活性代謝產物。Apovincaminic acid hydrochloride salt 具有神經(jīng)保護作用。體內研究
Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation.
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats.
| Animal Model: | Male Harlan‐Wistar rats (300-400 g) are injected NMDA |
| Dosage: | 10 mg/kg |
| Administration: | I.p. twice daily for 4 days |
| Result: |
Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation. |