71751-77-4
71751-77-4 結(jié)構式
基本信息
中文別名
化合物 T16035 英文別名
MELEAGRINMeleagrine
6-O-Methyloxaline, Meleagrine
[3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2(3H),5-dione
1H,5H-Imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-, (3E,7aR,12aS)-
常見問題列表
生物活性
Meleagri 是由青霉屬 (Penicillium) 真菌產(chǎn)生的具有抗微生物和抗增殖活性的羅奎福汀 C 衍生生物堿。Meleagrin 是一類 FabI 抑制劑。Meleagri 是一種主要的 c-Met 抑制實體，有助于控制 c-Met 依賴性轉(zhuǎn)移和侵襲性乳腺癌。體外研究
Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox.
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines.
體內(nèi)研究
Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model.