71678-03-0
中文名稱
3-[(十氫-1Β,2Β,4AΒ-三甲基-5-亞甲基-1-萘基)甲基]-2-羥基-5-甲氧基苯醌
英文名稱
ILIMAQUINONE
CAS
71678-03-0
分子式
C22H30O4
分子量
358.47
MOL 文件
71678-03-0.mol
71678-03-0 結(jié)構(gòu)式
基本信息
中文別名
3-[(十氫-1Β,2Β,4AΒ-三甲基-5-亞甲基-1-萘基)甲基]-2-羥基-5-甲氧基苯醌 英文別名
IQILIMAQUINONE
illimaquinone
(-)-Ilimaquinine
(-)-ILIMAQUINONE
5-Epiilimaquinone
Ilimaquinone - CAS 71678-03-0 - Calbiochem
3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
2-[[(1R,8aα)-1,2β,4aβ-Trimethyl-5-methylenedecalin-1α-yl]methyl]-3-hydroxy-6-methoxy-1,4-benzoquinone
物理化學(xué)性質(zhì)
熔點(diǎn)108-110℃ (pentane )
比旋光度D23 -23.2° (c = 1.12 in CHCl3)
沸點(diǎn)478.4±45.0 °C(Predicted)
密度1.14±0.1 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
酸度系數(shù)(pKa)2.92±0.50(Predicted)
形態(tài)紅色固體
顏色Light yellow to brown
常見問(wèn)題列表
生物活性
Ilimaquinone 是一種海洋海綿狀代謝產(chǎn)物，通過(guò) GADD153 介導(dǎo)的信號(hào)通路發(fā)揮抗腫瘤活性。Ilimaquinone 可以誘導(dǎo)高爾基體的囊泡化。Ilimaquinone 具有抗病毒，抗菌和抗炎活性。體外研究
Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI 50 s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively.
Cell Viability Assay
| Cell Line: | Prostate cancer PC-3 cells |
| Concentration: | 0.3, 1, 3, 10, and 30 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of PC-3 cells in a concentration-dependent manner. |
體內(nèi)研究
Ilimaquinone exhibits terminal elimination half-lives (T 1/2 =1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats.