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70704-03-9

中文名稱 長(zhǎng)春考酯
英文名稱 vinconate
CAS 70704-03-9
分子式 C18H20N2O2
分子量 296.36
MOL 文件 70704-03-9.mol
70704-03-9 結(jié)構(gòu)式 70704-03-9 結(jié)構(gòu)式

基本信息

中文別名
長(zhǎng)春考酯
英文別名
Vincote
Vintenate
vinconate
Chanodesethylapovinc?amine
1H-Indolo[3,2,1-de][1,5]naphthyridine-6-carboxylic acid, 3-ethyl-2,3,3a,4-tetrahydro-, methyl ester

物理化學(xué)性質(zhì)

熔點(diǎn)120-121°
沸點(diǎn)363.6±42.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.00±0.40(Predicted)

常見問題列表

生物活性
Vinconate 是一種吲哚萘啶衍生物,可以刺激毒蕈堿乙酰膽堿受體 (muscariic acetylcholine receptor)。
靶點(diǎn)

muscariic acetylcholine receptor

體內(nèi)研究

Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [ 3 H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [ 3 H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [ 3 H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [ 3 H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats.

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