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70181-03-2

中文名稱 達佐必利
英文名稱 Dazopride
CAS 70181-03-2
分子式 C15H23ClN4O2
分子量 326.82
MOL 文件 70181-03-2.mol
70181-03-2 結(jié)構(gòu)式 70181-03-2 結(jié)構(gòu)式

基本信息

中文別名
達佐必利
英文別名
AHR-5531
Dazopride
4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxybenzamide
4-Amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxybenzamide
Benzamide, 4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy-

物理化學(xué)性質(zhì)

密度1.27±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.31±0.20(Predicted)

常見問題列表

生物活性
Dazopride 是一種止吐劑。
體內(nèi)研究

Dazopride (0.3 mg/kg) produces significant enhancement of gastric evacuation and is approximately six times more potent than metoclopramide in gastric evacuation assay. Dazopride (0.3-10.0 mg/kg, i.v.) produces a dose-related increase in antral motility primarily by increasing the amplitude of antral contractions in three conscious dogs. Dazopride significantly reduces the emetic frequency from that of the control group. Dazopride (5 mg/kg, i.p.) antagonises the tetralin-induced emesis in all animals, but fails to antagonise the response at 0.25-2.5 mg/kg. Dazopride fails to modify cisplatin-induced emesis at 0.1 mg/kg (i.v,) although a larger dose of 1.0 mg/kg abolishes or attenuates the response and 5.0 mg/kg of dazopride antagonises the development ofemesis in all animals.

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