693288-97-0
中文名稱
N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺
英文名稱
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
CAS
693288-97-0
分子式
C22H15ClN2O4
分子量
406.82
MOL 文件
693288-97-0.mol
更新日期
2024/12/13 09:52:59
693288-97-0 結(jié)構(gòu)式
基本信息
中文別名
N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺 英文別名
CPPHAN-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide
N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
Benzamide, N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點539.7±50.0 °C(Predicted)
密度1.505
儲存條件-20°C
溶解度二甲基亞砜：>20mg/mL
酸度系數(shù)(pKa)8.24±0.30(Predicted)
形態(tài)固體
顏色Light yellow to yellow
N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-14612 | N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺 CPPHA | 693288-97-0 | 5mg | 700元 |
| 2024/11/08 | HY-14612 | N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺 CPPHA | 693288-97-0 | 10mM * 1mLin DMSO | 770元 |
| 2024/11/08 | HY-14612 | N-[4-氯-2-[(1,3-二氫-1,3-二氧代-2H-異吲哚-2-基)甲基]苯基]-2-羥基苯甲酰胺 CPPHA | 693288-97-0 | 10mg | 1300元 |
常見問題列表
生物活性
CPPHA 是一種高效、選擇性的代謝型谷氨酸受體 mGluR5 和 mGluR1 正向變構(gòu)調(diào)制器 (PAM)。CPPHA 可增強 mGluR5 和 mGluR1 對受體激活的反應(yīng)。CPPHA 被開發(fā)用于中樞神經(jīng)系統(tǒng)疾病的研究。靶點
|
mGlu5 Receptor
|
體外研究
CPPHA alone has no agonist activity.
CPPHA causes concentration-dependent potentiation of the response of human mGluR5 CHO cells to agonists.
CPPHA potentiates threshold response to glutamate in fluorometric Ca
2+
assays 7- to 8-fold with EC
50
values in the 400 to 800 nM range.
CPPHA (20 μM; 15 minutes) potentiates the response to a subthreshold concentration of DHPG (HY-12598A) on ERK and cyclic-AMP responsive element-binding protein (CREB) activity, as well as NMDA receptor subunit NR1 phosphorylation in cortical and hippocampal slices.
Western Blot Analysis
| Cell Line: | Rat hippocampal cells |
| Concentration: | 20 μM |
| Incubation Time: | 15 minutes |
| Result: | Potentiated the DHPG (20 μM)-induced increase in phosphorylation of ERK and CREB, approaching levels seen with 100 μM DHPG alone. |