成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>688342-78-1

688342-78-1

中文名稱 D-I03
英文名稱 D-I03
CAS 688342-78-1
分子式 C23H36N6S
分子量 428.64
MOL 文件 688342-78-1.mol
更新日期 2024/06/07 17:53:08
688342-78-1 結(jié)構(gòu)式 688342-78-1 結(jié)構(gòu)式

基本信息

中文別名
化合物D-I03
化合物 T10936
英文別名
D-I03
D-I03 (D103)

物理化學(xué)性質(zhì)

沸點582.0±60.0 °C(Predicted)
密度1.147±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: ≥ 100 mg/mL (233.30 mM)
酸度系數(shù)(pKa)12.00±0.70(Predicted)
形態(tài)Solid
顏色Off-white to light yellow

圖譜信息

常見問題列表

生物活性
D-I03 是一種 RAD52 的選擇性抑制劑,對應(yīng)的Kd值為25.8 μM。D-I03 通過 RAD52 和D環(huán)形成抑制ssDNA退火,對應(yīng)的IC50值分別為5 μM和8 μM。
靶點
TargetValue
RAD52
(Cell-free assay)
25.8 μM(Ki)
體外研究

D-I03 (0-10 μM; on days 1 and 3; Capan-1 and UWB1.289 cells) treatment preferentially suppressed the growth of Capan-1 and UWB1.289 cells in a concentration-dependent manner.
D-I03 inhibits RAD52 foci formation induced by cisplatin in BCR-ABL1-positive BRCA1-deficient 32Dcl3 murine hematopoietic cell line that expresses GFP-RAD52. In the presence of D-I03 (2.5 μM), the fraction of cells with RAD52 foci is decreased, from 38.7% to 171%; at the same time, the fraction of Cisplatin-treated cells without foci is increased from 48.4% to 71.9%. D-I03 does not effect on RAD51 foci induced by Cisplatin. Also, D-I03 alone induce neither RAD51 foci nor RAD52 foci (in BRCA1-deficient cells) indicating low genotoxicity of D-I03.

Cell Proliferation Assay

Cell Line: Capan-1 (BRCA2 ? ) and UWB1.289 (BRCA1 + ) cells
Concentration: 0 μM, 2.5 μM, 5 μM, or 10 μM
Incubation Time: On days 1 and 3
Result: Preferentially suppressed the growth of Capan-1 and UWB1.289 cells.
體內(nèi)研究

D-I03 (50 mg/kg/day; intraperitoneal injection; daily; for 7 days; nu/nu mice) treatment reduces BRCA1-deficient MDA-MB-436 tumor growth. Talazoparib puls D-I03 does not affect the growth of BRCA1-proficient tumors and does not exert any significant toxicity against normal tissues and organs.
Pharmacokinetic and toxicity studies indicates that maximal tolerated dose of D-I03 is ≥50 mg/kg, and t 1/2 is 23.4 hours, resulting in >1 μM maximal concentration in peripheral blood.

Animal Model: Nu/nu mice injected with BRCA1-deficient MDA-MB-436 cells
Dosage: 50 mg/kg/day
Administration: Intraperitoneal injection; daily; for 7 days
Result: Reduced BRCA1-deficient MDA-MB-436 tumor growth.
"688342-78-1" 相關(guān)產(chǎn)品信息